Predictive value and clinical impact of Basal follicle-stimulating hormone in subfertile, ovulatory women.
نویسندگان
چکیده
CONTEXT Basal FSH is a marker for ovarian reserve. OBJECTIVES The objective of the study was to investigate the predictive value of basal FSH on spontaneous ongoing pregnancy in subfertile ovulatory women. DESIGN This was a prospective cohort study. SETTING The study was conducted in 19 fertility centers in The Netherlands. PARTICIPANTS Subfertile ovulatory women without two-sided tubal pathology and in whom the man had normal sperm parameters (total motile count > or = 3 x10(6)) participated in the study. INTERVENTIONS Interventions included a fertility work-up, including a basal FSH measurement on cycle d 3. MAIN OUTCOME MEASURES Spontaneous ongoing pregnancy was measured. RESULTS We included 3519 consecutive couples of which 562 (16%) had a spontaneous ongoing pregnancy within 1 yr. Basal FSH levels of 8 IU/liter or higher were associated with a decreased probability of spontaneous ongoing pregnancy [hazard ratio (HR) 0.93/IU.liter (95% confidence interval [CI] 0.87-0.98)]. In a multivariable analysis, female age (HR 0.97/yr, 95% CI 0.95-0.99), cycle length (HR 0.96/d, 95% CI 0.93-1.0), and FSH levels 8 IU/liter or greater (HR 0.93/IU.liter, 95% CI 0.87-0.99) were strong negative predictors for spontaneous ongoing pregnancy. Addition of FSH to a prediction model based on female age, duration of subfertility, previous pregnancy, referral status, and semen analysis changed the probability to conceive spontaneously from 30% or greater to less than 30% in 97 of 3219 couples (3.0%). CONCLUSIONS In ovulatory women, a basal FSH level of 8 IU/liter or higher is associated with decreasing fecundity, independent of female age and cycle length. Because the number of couples in whom the FSH level alters management decisions is low, we do not recommend routine testing of basal FSH in subfertile couples.
منابع مشابه
The predictive value of ovarian reserve tests for miscarriage in a population of subfertile ovulatory women.
BACKGROUND The increase in miscarriage rate with female age is attributed to a decline in oocyte quality. This age-related decrease of oocyte quality is accompanied by a decrease in oocyte quantity. Assessment of the number of oocytes by ovarian reserve tests (ORTs) may therefore also represent their quality. The objective of our study was to assess the predictive value of ORTs for miscarriage ...
متن کاملThe predictive value of ovarian reserve tests for spontaneous pregnancy in subfertile ovulatory women.
BACKGROUND The predictive value of ovarian reserve tests (ORTs) for spontaneous pregnancy is unclear. Our study aimed to determine whether ORTs have added value to previously identified prognostic factors for spontaneous pregnancy in subfertile ovulatory couples. METHODS A prospective cohort study was performed on 474 subfertile ovulatory couples in two hospitals in Groningen, The Netherlands...
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ورودعنوان ژورنال:
- The Journal of clinical endocrinology and metabolism
دوره 92 6 شماره
صفحات -
تاریخ انتشار 2007